The curriculum
Twenty-four lessons across four tracks. Foundations are prerequisite in the real sense: the upper division assumes you can already convert a unit and read a concentration. Everything is free, and everything stays free.
What a peptide is, and what it is not
Structure, signalling, and arithmetic. By the end of this track you should be able to read any vial label, state what the compound is meant to bind to, and calculate a dose without a calculator, or know precisely why you cannot.
- 01 What a Peptide Actually Is Amino acids, the peptide bond, and where the line sits between a peptide, a protein, and a small molecule. Why the distinction determines everything about how a compound behaves. 9 min
- 02 Receptors, Agonists, and Half-Life How a signalling molecule produces an effect, what agonist and antagonist mean, and why half-life is the number that quietly governs dosing frequency. 11 min
- 03 The Legal and Regulatory Landscape Approved drug, compounded preparation, research chemical, and outright unapproved: four different legal categories that are routinely discussed as though they were one. 10 min
- 04 Milligrams, Micrograms, and Units mg, mcg, IU, and the marks on a U-100 barrel. Four scales that measure different things and get used interchangeably by people who should know better. 8 min
- 05 Reconstitution and Dose Math Lyophilised powder, bacteriostatic water, resulting concentration, and the mark you actually draw to. Worked from first principles, with the three classic decimal errors. 14 min
- 06 Storage, Sterility, and Handling Cold chain, light, agitation, and the difference between bacteriostatic and sterile water. Why a peptide degrades and what that costs you. 10 min
- 07 Risk Literacy Known risk, unknown risk, and unknowable risk are three different things. How to reason about a compound with eleven human subjects behind it, and when the honest answer is that nobody knows. 12 min
A survey of the major families
One lesson per class. Each covers mechanism first, then the evidence base honestly graded, then the failure modes. No protocols, no recommendations. The mechanism is the lesson.
- 01 Incretins: GLP-1, GIP, and the Metabolic Class The receptor biology behind the most consequential peptide class of the decade, and why dual and triple agonists behave differently from single. Soon
- 02 Repair and Recovery BPC-157 and TB-500: the mechanisms proposed, the animal literature, and the considerable distance between the two. Soon
- 03 Growth Hormone Secretagogues GHRH analogues, ghrelin mimetics, and the pulsatility problem that makes this class harder to reason about than it looks. Soon
- 04 Cosmetic and Dermatological GHK-Cu, the melanocortin compounds, and a class where the risk profile is frequently understated. Soon
- 05 Neurological and Nootropic Semax, Selank, and the regional-approval problem: widely prescribed in one country, entirely unstudied in most others. Soon
- 06 Sexual Health The melanocortin pathway, an approved drug in the class, and what approval did and did not settle. Soon
- 07 Longevity and Mitochondrial Epitalon, MOTS-c, SS-31: the thinnest evidence base in the curriculum, taught as an exercise in reading thin evidence. Soon
Verification and the grey market
This track teaches document literacy, not sourcing. We do not name vendors and we never will. What we will teach is how to read what a vendor hands you and identify what it fails to say.
- 01 How the Grey Market Actually Works Synthesis, brokerage, relabelling, and the structural reasons a chain of custody is usually unverifiable. Soon
- 02 Reading a Certificate of Analysis Every field on the document, what each one means, and which absences matter more than the numbers present. Soon
- 03 HPLC, Mass Spec, and What Each Proves Purity is not identity and identity is not quantity. Three tests answering three different questions, routinely conflated into one claim. Soon
- 04 Third-Party Testing Who tests, who pays, what independence means in practice, and why a batch number is the most important line on the page. Soon
- 05 Counterfeits, Underdosing, Contamination The three ways product goes wrong, ranked by how often they occur versus how often they are discussed. Soon
Baselines, monitoring, and stopping
The track about measurement. If you cannot describe what you are measuring and what number would make you stop, you are not running an experiment. You are just hoping.
- 01 Establishing a Baseline What to record before anything changes, and why a baseline taken afterwards is not a baseline. Soon
- 02 Bloodwork: Which Markers, Which Intervals Reading a panel, understanding reference ranges, and the markers most relevant to the classes covered in 201. Soon
- 03 Tolerance, Desensitisation, Cycling Receptor downregulation as a mechanism rather than a folk belief, and what it implies about scheduling. Soon
- 04 Interactions and Stacking Logic Why combining two compounds multiplies unknowns rather than adding them, and how interaction risk is usually assessed badly. Soon
- 05 When to Stop and See a Physician The signals that end the conversation. The shortest lesson in the curriculum and the one that matters most. Soon
Questions the syllabus didn't anticipate
Lessons in preparation get drafted, argued over, and corrected in the Discord before they are published here. If you want to see how the sausage is made, or object to how it is being made, that is where to do it.